Karine Guillem

Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (INCIA)

Title

Aberrant neuronal and gamma activities in the ventromedial prefrontal cortex in nicotine withdrawal-induced attentional deficits.

Biosketch

I have been conducting behavioral experimental research in rodents, mainly on drug addiction, for 20 years. After a PhD obtained in 2005 in Bordeaux on the role of the co-factors present in tobacco smoke on the addictive properties of nicotine, I moved to the laboratory of Dr Laura Peoples in Philadelphia where I study the neurophysiological processes underlying drug addiction using in vivo electrophysiological recordings in behaving animals. Then I joined the laboratory of Pr. Huibert Mansvelder in Amsterdam studying the role of the nicotinic receptor subunits in attention processus using viral-based approaches. Since 2011, I am a tenured Research Associate at CNRS working in the team of Dr. Serge Ahmed "Choice, Addiction and Neurodysfunction" at the Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (INCIA).

I have a recognized expertise in the neurophysiology of drug addiction using in vivo electrophysiological recordings in behaving animals during drug-taking and drug-seeking behaviors. Recently, I have extended my expertise to the neuronal processes underlying attention and decision-making within the prefrontal and orbitofrontal cortex using optogenetic and chemogenetic stimulation methods.