Mathias Groszer
Inserm, Sorbonne Université, Institut du Fer à Moulin, Paris, France
Title
Approaching human neurodevelopment through studying of rare mutations
Research
Matthias Groszer's team studies neurodevelopmental disorders with the ultimate aim to
identify key molecular and cellular mechanisms involved in establishing
neuronal circuits underlying social cognition and behavior. They currently
focus on the study of transcription factors whose mutations lead to
speech and language disorder and to microcephaly and intellectual
disability.
They aim to dissect the molecular targets of these
transcription factors and their roles in neuronal physiology and
behavior. In order to tackle these issues, they employ state of the art
complementary methods in molecular genetics, cell biology,
electrophysiology and optogenetics in genetic mouse models and human
iPSC-derived neurons. Eventually their research should contribute to a
better understanding of complex neurodevelopmental syndromes which
affect the ‘social brain’ such as autisms or related disorders.