Marie-Laure Arotçarena

UMR 5293 - Institut des Maladies Neurodégénératives

Title

Boosting autophagy as potential therapeutic strategies for Parkinson’s disease

Abstract

Synucleinopathies are neurodegenerative diseases characterized by the presence of α-synuclein-positive intracytoplasmic inclusions into the central nervous system. Increasing evidence indicates that impairment of lysosomal function may contribute to the pathogenesis of the synucleinopathies, including Parkinson’s Disease and Multiple system atrophy. We and others have shown that inducing autophagy, through chemical and/or genetic approaches, is an effective and promising therapeutic strategy for synucleinopathies.